MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti- tumor effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely understood. The aim of this paper was to explore the mechanisms and new drug targets to treat DOX-induced...

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Detalles Bibliográficos
Autores principales: Zhao, Lisha, Qi, Yan, Xu, Lina, Tao, Xufeng, Han, Xu, Yin, Lianhong, Peng, Jinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975069/
https://www.ncbi.nlm.nih.gov/pubmed/29304479
http://dx.doi.org/10.1016/j.redox.2017.12.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975069/
https://www.ncbi.nlm.nih.gov/pubmed/29304479
http://dx.doi.org/10.1016/j.redox.2017.12.013

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