Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Hallmarks of cancer cells include uncontrolled growth and rapid proliferation; thus, cyclin-dependent kinases are a therapeutic target for cancer treatment. Treating non-small lung cancer cells with sublethal concentrations of the CDK4/6 inhibitors, ribociclib (LEE011) and palbociclib (PD0332991), w...

Descripción completa

Detalles Bibliográficos
Autores principales: Tempka, Dominika, Tokarz, Paulina, Chmielewska, Kinga, Kluska, Magdalena, Pietrzak, Julita, Rygielska, Żaneta, Virág, László, Robaszkiewicz, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975074/
https://www.ncbi.nlm.nih.gov/pubmed/29306194
http://dx.doi.org/10.1016/j.redox.2017.12.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975074/
https://www.ncbi.nlm.nih.gov/pubmed/29306194
http://dx.doi.org/10.1016/j.redox.2017.12.017

Ejemplares similares