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Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

Hallmarks of cancer cells include uncontrolled growth and rapid proliferation; thus, cyclin-dependent kinases are a therapeutic target for cancer treatment. Treating non-small lung cancer cells with sublethal concentrations of the CDK4/6 inhibitors, ribociclib (LEE011) and palbociclib (PD0332991), w...

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Detalles Bibliográficos
Autores principales:	Tempka, Dominika, Tokarz, Paulina, Chmielewska, Kinga, Kluska, Magdalena, Pietrzak, Julita, Rygielska, Żaneta, Virág, László, Robaszkiewicz, Agnieszka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975074/ https://www.ncbi.nlm.nih.gov/pubmed/29306194 http://dx.doi.org/10.1016/j.redox.2017.12.017

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