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Kinetic and structural comparison of a protein’s cotranslational folding and refolding pathways
Precise protein folding is essential for the survival of all cells, and protein misfolding causes a number of diseases that lack effective therapies, yet the general principles governing protein folding in the cell remain poorly understood. In vivo, folding can begin cotranslationally and protein qu...
Autores principales: | Samelson, Avi J., Bolin, Eric, Costello, Shawn M., Sharma, Ajeet K., O’Brien, Edward P., Marqusee, Susan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976279/ https://www.ncbi.nlm.nih.gov/pubmed/29854950 http://dx.doi.org/10.1126/sciadv.aas9098 |
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