Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials

Currently, drug development efforts and clinical trials to test them are often prioritized by targeting genes with high frequencies of somatic variants among tumors. However, differences in oncogenic mutation rate—not necessarily the effect the variant has on tumor growth—contribute enormously to so...

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Detalles Bibliográficos
Autores principales: Wilkins, Jon F., Cannataro, Vincent L., Shuch, Brian, Townsend, Jeffrey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976461/
https://www.ncbi.nlm.nih.gov/pubmed/29854275
http://dx.doi.org/10.18632/oncotarget.25155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976461/
https://www.ncbi.nlm.nih.gov/pubmed/29854275
http://dx.doi.org/10.18632/oncotarget.25155

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