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Analysis of mutation, selection, and epistasis: an informed approach to cancer clinical trials
Currently, drug development efforts and clinical trials to test them are often prioritized by targeting genes with high frequencies of somatic variants among tumors. However, differences in oncogenic mutation rate—not necessarily the effect the variant has on tumor growth—contribute enormously to so...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976461/ https://www.ncbi.nlm.nih.gov/pubmed/29854275 http://dx.doi.org/10.18632/oncotarget.25155 |