Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models

The tumor vasculature differs from normal blood vessels in morphology, composition and stability. Here, we describe a novel tumor vessel-disrupting mechanism. In an HT1080/mouse xenograft tumor model rhodocetin-αβ was highly effective in disrupting the tumor endothelial barrier. Mechanistically, rho...

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Detalles Bibliográficos
Autores principales: Niland, Stephan, Komljenovic, Dorde, Macas, Jadranka, Bracht, Thilo, Bäuerle, Tobias, Liebner, Stefan, Eble, Johannes A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976474/
https://www.ncbi.nlm.nih.gov/pubmed/29854288
http://dx.doi.org/10.18632/oncotarget.25032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976474/
https://www.ncbi.nlm.nih.gov/pubmed/29854288
http://dx.doi.org/10.18632/oncotarget.25032

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