Early Treatment of SIV+ macaques with an α(4)β(7) mAb alters virus distribution and preserves CD4(+) T cells in later stages of infection

Integrin α(4)β(7) mediates the trafficking of leukocytes, including CD4(+) T cells, to lymphoid tissues in the gut. Virus mediated damage to the gut is implicated in HIV and SIV mediated chronic immune activation and leads to irreversible damage to the immune system. We employed an immuno-PET/CT ima...

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Detalles Bibliográficos
Autores principales: Santangelo, Philip J., Cicala, Claudia, Byrareddy, Siddappa N., Ortiz, Kristina, Little, Dawn, Lindsay, Kevin E., Gumber, Sanjeev, Hong, J. J., Jelicic, Katija, Rogers, Kenneth A., Zurla, Chiara, Villinger, Francois, Ansari, Aftab A., Fauci, Anthony S., Arthos, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976508/
https://www.ncbi.nlm.nih.gov/pubmed/29346349
http://dx.doi.org/10.1038/mi.2017.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976508/
https://www.ncbi.nlm.nih.gov/pubmed/29346349
http://dx.doi.org/10.1038/mi.2017.112

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