Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

Ulcerative colitis (UC) patients exhibit elevated histamine, but how histamine exacerbates disease is unclear since targeting histamine 1 receptor (H1R) or H2R is clinically ineffective. We hypothesized that histamine functioned instead through the other colon-expressed histamine receptor, H4R. In h...

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Detalles Bibliográficos
Autores principales: Wechsler, Joshua B., Szabo, Alison, Hsu, Chia-Lin, Krier-Burris, Rebecca, Schroeder, Holly, Wang, Ming Y., Carter, Roderick, Velez, Tania, Aguiniga, Lizath M., Brown, Jeff B., Miller, Mendy L., Wershil, Barry K., Barrett, Terrence A., Bryce, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976516/
https://www.ncbi.nlm.nih.gov/pubmed/29363669
http://dx.doi.org/10.1038/mi.2017.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976516/
https://www.ncbi.nlm.nih.gov/pubmed/29363669
http://dx.doi.org/10.1038/mi.2017.121

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