Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis

Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4(+) T cells. Nup210-deficient CD4(+) T lymphocytes develop normally but fail to survive in the periphery. The decr...

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Detalles Bibliográficos
Autores principales: Borlido, Joana, Sakuma, Stephen, Raices, Marcela, Carrette, Florent, Tinoco, Roberto, Bradley, Linda M., D’Angelo, Maximiliano A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976539/
https://www.ncbi.nlm.nih.gov/pubmed/29736031
http://dx.doi.org/10.1038/s41590-018-0103-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976539/
https://www.ncbi.nlm.nih.gov/pubmed/29736031
http://dx.doi.org/10.1038/s41590-018-0103-5

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