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Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis
Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4(+) T cells. Nup210-deficient CD4(+) T lymphocytes develop normally but fail to survive in the periphery. The decr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976539/ https://www.ncbi.nlm.nih.gov/pubmed/29736031 http://dx.doi.org/10.1038/s41590-018-0103-5 |