Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues

High-mobility group box 1 (HMGB1) protein acts as a DNA chaperone for nuclear homeostasis. It translocates into the cytosol and is secreted into extracellular spaces, triggering proinflammatory cytokines and acting as a mediator in fibrosis. We determined whether HMGB1 plays a role in normal dermal...

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Detalles Bibliográficos
Autores principales: Lee, Won Jai, Song, Seung Yong, Roh, Hyun, Ahn, Hyo Min, Na, Youjin, Kim, Jihee, Lee, Ju Hee, Yun, Chae Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976629/
https://www.ncbi.nlm.nih.gov/pubmed/29849053
http://dx.doi.org/10.1038/s41598-018-26501-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976629/
https://www.ncbi.nlm.nih.gov/pubmed/29849053
http://dx.doi.org/10.1038/s41598-018-26501-6

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