eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

Cachexia is a deadly muscle wasting syndrome that arises under conditions linked to chronic inflammation, such as cancer. Cytokines, including interferon γ (IFNγ), tumor necrosis factor α (TNFα) and interleukin-6 (IL-6), and their downstream effectors such as Signal Transducer and Activator of Trans...

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Detalles Bibliográficos
Autores principales: Cramer, Zvi, Sadek, Jason, Vazquez, Gabriela Galicia, Di Marco, Sergio, Pause, Arnim, Pelletier, Jerry, Gallouzi, Imed-Eddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976662/
https://www.ncbi.nlm.nih.gov/pubmed/29849089
http://dx.doi.org/10.1038/s41598-018-26625-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976662/
https://www.ncbi.nlm.nih.gov/pubmed/29849089
http://dx.doi.org/10.1038/s41598-018-26625-9

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