Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5

The production of antibodies against the extracellular regions (ECR) of multispanning membrane proteins is notoriously difficult because of the low productivity and immunogenicity of membrane proteins due to their complex structure and highly conserved sequences among species. Here, we introduce a n...

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Detalles Bibliográficos
Autores principales: Hashimoto, Yosuke, Zhou, Wei, Hamauchi, Kohtaroh, Shirakura, Keisuke, Doi, Takefumi, Yagi, Kiyohito, Sawasaki, Tatsuya, Okada, Yoshiaki, Kondoh, Masuo, Takeda, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976803/
https://www.ncbi.nlm.nih.gov/pubmed/29849184
http://dx.doi.org/10.1038/s41598-018-26560-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976803/
https://www.ncbi.nlm.nih.gov/pubmed/29849184
http://dx.doi.org/10.1038/s41598-018-26560-9

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