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Engineered membrane protein antigens successfully induce antibodies against extracellular regions of claudin-5
The production of antibodies against the extracellular regions (ECR) of multispanning membrane proteins is notoriously difficult because of the low productivity and immunogenicity of membrane proteins due to their complex structure and highly conserved sequences among species. Here, we introduce a n...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976803/ https://www.ncbi.nlm.nih.gov/pubmed/29849184 http://dx.doi.org/10.1038/s41598-018-26560-9 |