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Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas
The nuclease Artemis is essential for the development of T-cell and B-cell receptors and repair of DNA double-strand breaks, and a loss of expression or function will lead to a radiosensitive severe combined immunodeficiency with no functional T-cells or B-cells (T-B-SCID). Hypomorphic mutations in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977007/ https://www.ncbi.nlm.nih.gov/pubmed/29888014 http://dx.doi.org/10.1155/2018/2053716 |