Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches

Polio viral proteinase 2A performs several essential functions in genome replication. Its inhibition prevents viral replication, thus making it an excellent substrate for drug development. In this study, the three-dimensional structure of 2A protease was determined and optimized by homology modellin...

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Detalles Bibliográficos
Autores principales: Younus, Amna, Munawar, Saba, Bhatti, Muhammad Faraz, Ikram, Aqsa, Awan, Faryal Mehwish, Jabeen, Ishrat, Virk, Nasar, Janjua, Hussnain Ahmed, Arshad, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977168/
https://www.ncbi.nlm.nih.gov/pubmed/29701718
http://dx.doi.org/10.3390/genes9050228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977168/
https://www.ncbi.nlm.nih.gov/pubmed/29701718
http://dx.doi.org/10.3390/genes9050228

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