Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with nume...

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Detalles Bibliográficos
Autores principales: Mutso, Margit, Morro, Ainhoa Moliner, Smedberg, Cecilia, Kasvandik, Sergo, Aquilimeba, Muriel, Teppor, Mona, Tarve, Liisi, Lulla, Aleksei, Lulla, Valeria, Saul, Sirle, Thaa, Bastian, McInerney, Gerald M, Merits, Andres, Varjak, Margus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977219/
https://www.ncbi.nlm.nih.gov/pubmed/29702546
http://dx.doi.org/10.3390/v10050226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977219/
https://www.ncbi.nlm.nih.gov/pubmed/29702546
http://dx.doi.org/10.3390/v10050226

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