NMR analyses on N-hydroxymethylated nucleobases – implications for formaldehyde toxicity and nucleic acid demethylases

Formaldehyde is produced in cells by enzyme-catalysed demethylation reactions, including those occurring on N-methylated nucleic acids. Formaldehyde reacts with nucleobases to form N-hydroxymethylated adducts that may contribute to its toxicity/carcinogenicity when added exogenously, but the chemist...

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Detalles Bibliográficos
Autores principales: Shishodia, S., Zhang, D., El-Sagheer, A. H., Brown, T., Claridge, T. D. W., Schofield, C. J., Hopkinson, R. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977384/
https://www.ncbi.nlm.nih.gov/pubmed/29767200
http://dx.doi.org/10.1039/c8ob00734a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977384/
https://www.ncbi.nlm.nih.gov/pubmed/29767200
http://dx.doi.org/10.1039/c8ob00734a

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