Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment

A tripartite cancer vaccine candidate, containing a quaternary amino acid (α-methylserine) in the most immunogenic domain of MUC1, has been synthesized and examined for antigenic properties in transgenic mice. The vaccine which is glycosylated with GalNAc at the unnatural amino acid, was capable of...

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Detalles Bibliográficos
Autores principales: Martínez-Sáez, Nuria, Supekar, Nitin T., Wolfert, Margreet A., Bermejo, Iris A., Hurtado-Guerrero, Ramón, Asensio, Juan L., Jiménez-Barbero, Jesús, Busto, Jesús H., Avenoza, Alberto, Boons, Geert-Jan, Peregrina, Jesús M., Corzana, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977504/
https://www.ncbi.nlm.nih.gov/pubmed/29910919
http://dx.doi.org/10.1039/c5sc04039f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977504/
https://www.ncbi.nlm.nih.gov/pubmed/29910919
http://dx.doi.org/10.1039/c5sc04039f

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