Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro

Glioblastoma is the most aggressive type of glioma. The Wingless (Wnt) signaling pathway has been shown to promote stem cell properties and resistance to radio- and chemotherapy in glioblastoma. Here, we demonstrate that pharmacological Wnt pathway inhibition using the porcupine inhibitor LGK974 act...

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Detalles Bibliográficos
Autores principales: Suwala, Abigail Kora, Koch, Katharina, Rios, Dayana Herrera, Aretz, Philippe, Uhlmann, Constanze, Ogorek, Isabella, Felsberg, Jörg, Reifenberger, Guido, Köhrer, Karl, Deenen, René, Steiger, Hans-Jakob, Kahlert, Ulf D., Maciaczyk, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978259/
https://www.ncbi.nlm.nih.gov/pubmed/29854309
http://dx.doi.org/10.18632/oncotarget.25210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978259/
https://www.ncbi.nlm.nih.gov/pubmed/29854309
http://dx.doi.org/10.18632/oncotarget.25210

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