Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40–CD154 Costimulatory Protein-Protein Interaction

We report the design, synthesis, and testing of novel small-molecule compounds targeting the CD40–CD154 (CD40L) costimulatory interaction for immunomodulatory purposes. This protein-protein interaction (PPI) is a TNF-superfamily (TNFSF) costimulatory interaction that is an important therapeutic targ...

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Detalles Bibliográficos
Autores principales: Bojadzic, Damir, Chen, Jinshui, Alcazar, Oscar, Buchwald, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978685/
https://www.ncbi.nlm.nih.gov/pubmed/29751636
http://dx.doi.org/10.3390/molecules23051153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978685/
https://www.ncbi.nlm.nih.gov/pubmed/29751636
http://dx.doi.org/10.3390/molecules23051153

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