Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme

Ligand binding sites in proteins are often localized to deeply buried cavities, inaccessible to bulk solvent. Yet, in many cases binding of cognate ligands occurs rapidly. An intriguing system is presented by the L99A cavity mutant of T4 Lysozyme (T4L L99A) that rapidly binds benzene (~10(6) M(-1)s(...

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Detalles Bibliográficos
Autores principales: Mondal, Jagannath, Ahalawat, Navjeet, Pandit, Subhendu, Kay, Lewis E., Vallurupalli, Pramodh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979041/
https://www.ncbi.nlm.nih.gov/pubmed/29775455
http://dx.doi.org/10.1371/journal.pcbi.1006180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979041/
https://www.ncbi.nlm.nih.gov/pubmed/29775455
http://dx.doi.org/10.1371/journal.pcbi.1006180

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