In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites

BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently...

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Detalles Bibliográficos
Autores principales: Hu, Yan, Miller, Melanie, Zhang, Bo, Nguyen, Thanh-Thanh, Nielsen, Martin K., Aroian, Raffi V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979042/
https://www.ncbi.nlm.nih.gov/pubmed/29775454
http://dx.doi.org/10.1371/journal.pntd.0006506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979042/
https://www.ncbi.nlm.nih.gov/pubmed/29775454
http://dx.doi.org/10.1371/journal.pntd.0006506

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