4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H(3) Receptor Antagonist: Further Structure–Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation

Presynaptic histamine H(3) receptors (H(3)R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in the central nervous system (CNS). The extracellular levels of several neurotransmitters are enhanced by H(3)R antagonists, and there is a...

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Detalles Bibliográficos
Autores principales: Olszewska, Beata, Stasiak, Anna, McNaught Flores, Daniel, Fogel, Wiesława Agnieszka, Leurs, Rob, Walczyński, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979327/
https://www.ncbi.nlm.nih.gov/pubmed/29671795
http://dx.doi.org/10.3390/ijms19041243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979327/
https://www.ncbi.nlm.nih.gov/pubmed/29671795
http://dx.doi.org/10.3390/ijms19041243

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