Oligodendroglioma Cells Lack Glutamine Synthetase and Are Auxotrophic for Glutamine, but Do not Depend on Glutamine Anaplerosis for Growth

In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS), the only enzyme that catalyzes de novo Gln s...

Descripción completa

Detalles Bibliográficos
Autores principales: Chiu, Martina, Taurino, Giuseppe, Bianchi, Massimiliano G., Ottaviani, Laura, Andreoli, Roberta, Ciociola, Tecla, Lagrasta, Costanza A. M., Tardito, Saverio, Bussolati, Ovidio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979401/
https://www.ncbi.nlm.nih.gov/pubmed/29642388
http://dx.doi.org/10.3390/ijms19041099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979401/
https://www.ncbi.nlm.nih.gov/pubmed/29642388
http://dx.doi.org/10.3390/ijms19041099

Ejemplares similares