Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine

Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. Cytotoxicity of N-benzylsecoboldine hydrochloride (BSB), a synthetic de...

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Detalles Bibliográficos
Autores principales: Kazemi Noureini, Sakineh, Kheirabadi, Mitra, Masoumi, Fatima, Khosrogerdi, Farve, Zarei, Younes, Suárez-Rozas, Cristian, Salas-Norambuena, Julio, Kennedy Cassels, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979471/
https://www.ncbi.nlm.nih.gov/pubmed/29671783
http://dx.doi.org/10.3390/ijms19041239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979471/
https://www.ncbi.nlm.nih.gov/pubmed/29671783
http://dx.doi.org/10.3390/ijms19041239

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