CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression

Gene and cellular therapies hold tremendous promise as agents for treating genetic disorders. However, the effective delivery of genes, particularly large ones, and expression at therapeutic levels can be challenging in cells of clinical relevance. To address this engineering hurdle, we sought to em...

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Detalles Bibliográficos
Autores principales: Osborn, Mark J., Lees, Christopher J., McElroy, Amber N., Merkel, Sarah C., Eide, Cindy R., Mathews, Wendy, Feser, Colby J., Tschann, Madison, McElmury, Ron T., Webber, Beau R., Kim, Chong Jai, Blazar, Bruce R., Tolar, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979553/
https://www.ncbi.nlm.nih.gov/pubmed/29565806
http://dx.doi.org/10.3390/ijms19040946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979553/
https://www.ncbi.nlm.nih.gov/pubmed/29565806
http://dx.doi.org/10.3390/ijms19040946

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