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PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells

Due to the high-level of metastatic and relapsed rates, rhabdomyosarcoma (RD) patients have a poor prognosis, and novel treatment strategies are required. Thereby, the present study evaluated the efficacy of PFK15, a PFKFB3 inhibitor, in RD cells to explore its potential underlying mechanism on the...

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Detalles Bibliográficos
Autores principales: Wang, Chunhui, Qu, Jianghong, Yan, Siyuan, Gao, Quan, Hao, Sibin, Zhou, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979828/
https://www.ncbi.nlm.nih.gov/pubmed/29620138
http://dx.doi.org/10.3892/ijmm.2018.3599