Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs, and various inhibitors have been reported in the literature. However, none of the reported potent inhibitors of human mPGES-1 has...

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Detalles Bibliográficos
Autores principales: Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979965/
https://www.ncbi.nlm.nih.gov/pubmed/29581541
http://dx.doi.org/10.1038/s41598-018-23482-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979965/
https://www.ncbi.nlm.nih.gov/pubmed/29581541
http://dx.doi.org/10.1038/s41598-018-23482-4

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