Impairment of K‐Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR‐143

Despite considerable research on K‐Ras inhibitors, none had been established until now. We synthesized nuclease‐resistant synthetic miR‐143 (miR‐143#12), which strongly silenced K‐Ras, its effector signal molecules AKT and ERK, and the K‐Ras activator Sos1. We examined the anti‐proliferative effect...

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Detalles Bibliográficos
Autores principales: Akao, Yukihiro, Kumazaki, Minami, Shinohara, Haruka, Sugito, Nobuhiko, Kuranaga, Yuki, Tsujino, Takuya, Yoshikawa, Yuki, Kitade, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980131/
https://www.ncbi.nlm.nih.gov/pubmed/29498789
http://dx.doi.org/10.1111/cas.13559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980131/
https://www.ncbi.nlm.nih.gov/pubmed/29498789
http://dx.doi.org/10.1111/cas.13559

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