Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of prostate cancer displaying hyperactive Akt. PTEN-defic...

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Detalles Bibliográficos
Autores principales: Nogueira, Veronique, Patra, Krushna C, Hay, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980228/
https://www.ncbi.nlm.nih.gov/pubmed/29687779
http://dx.doi.org/10.7554/eLife.32213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980228/
https://www.ncbi.nlm.nih.gov/pubmed/29687779
http://dx.doi.org/10.7554/eLife.32213

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