Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma

Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is an effective immunotherapy for B-cell malignancies but has failed in some solid tumors clinically. Intracerebral tumors may pose challenges that are even more significant. In order to devise a treatment strategy for patient...

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Detalles Bibliográficos
Autores principales: Suryadevara, Carter M., Desai, Rupen, Abel, Melissa L., Riccione, Katherine A., Batich, Kristen A., Shen, Steven H., Chongsathidkiet, Pakawat, Gedeon, Patrick C., Elsamadicy, Aladine A., Snyder, David J., Herndon, James E., Healy, Patrick, Archer, Gary E., Choi, Bryan D., Fecci, Peter E., Sampson, John H., Sanchez-Perez, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980382/
https://www.ncbi.nlm.nih.gov/pubmed/29872570
http://dx.doi.org/10.1080/2162402X.2018.1434464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980382/
https://www.ncbi.nlm.nih.gov/pubmed/29872570
http://dx.doi.org/10.1080/2162402X.2018.1434464

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