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Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma
Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is an effective immunotherapy for B-cell malignancies but has failed in some solid tumors clinically. Intracerebral tumors may pose challenges that are even more significant. In order to devise a treatment strategy for patient...
Autores principales: | Suryadevara, Carter M., Desai, Rupen, Abel, Melissa L., Riccione, Katherine A., Batich, Kristen A., Shen, Steven H., Chongsathidkiet, Pakawat, Gedeon, Patrick C., Elsamadicy, Aladine A., Snyder, David J., Herndon, James E., Healy, Patrick, Archer, Gary E., Choi, Bryan D., Fecci, Peter E., Sampson, John H., Sanchez-Perez, Luis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980382/ https://www.ncbi.nlm.nih.gov/pubmed/29872570 http://dx.doi.org/10.1080/2162402X.2018.1434464 |
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