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Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia
BACKGROUND AND PURPOSE: Enhanced late sodium current (late I (Na)) in heart failure and long QT syndrome type 3 is proarrhythmic. This study investigated the antiarrhythmic effect and mode of action of the selective and potent late I (Na) inhibitor GS‐458967 (GS967) against Torsades de Pointes arrhy...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980463/ https://www.ncbi.nlm.nih.gov/pubmed/29582428 http://dx.doi.org/10.1111/bph.14217 |