Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake

Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In order to find novel inhibitors of putrescine upta...

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Detalles Bibliográficos
Autores principales: Alberca, Lucas N., Sbaraglini, María L., Morales, Juan F., Dietrich, Roque, Ruiz, María D., Pino Martínez, Agustina M., Miranda, Cristian G., Fraccaroli, Laura, Alba Soto, Catalina D., Carrillo, Carolina, Palestro, Pablo H., Talevi, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981162/
https://www.ncbi.nlm.nih.gov/pubmed/29888213
http://dx.doi.org/10.3389/fcimb.2018.00173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981162/
https://www.ncbi.nlm.nih.gov/pubmed/29888213
http://dx.doi.org/10.3389/fcimb.2018.00173

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