Thermodynamic and NMR Assessment of Ligand Cooperativity and Intersubunit Communication in Symmetric Dimers: Application to Thymidylate Synthase

Thymidylate synthase (TS) is a homodimeric enzyme with evidence for negative regulation of one protomer while the other protomer acts on substrate, so called half-the-sites reactivity. The mechanisms by which multisubunit allosteric proteins communicate between protomers is not well understood, and...

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Detalles Bibliográficos
Autores principales: Lee, Andrew L., Sapienza, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981203/
https://www.ncbi.nlm.nih.gov/pubmed/29888227
http://dx.doi.org/10.3389/fmolb.2018.00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981203/
https://www.ncbi.nlm.nih.gov/pubmed/29888227
http://dx.doi.org/10.3389/fmolb.2018.00047

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