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BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path

Bovine pancreatic trypsin inhibitor (BPTI) is a 58-residue protein that is stabilized by three disulfide bonds at positions 5–55, 14–38 and 30–51. Widely studied for about 50 years, BPTI represents a folding model for many disulfide-rich proteins. In the study described below, we replaced the solven...

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Detalles Bibliográficos
Autores principales: Mousa, Reem, Lansky, Shifra, Shoham, Gil, Metanis, Norman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982216/
https://www.ncbi.nlm.nih.gov/pubmed/29910933
http://dx.doi.org/10.1039/c8sc01110a