Exploring the Structural Diversity in Inhibitors of α-Synuclein Amyloidogenic Folding, Aggregation, and Neurotoxicity

Aggregation of α-Synuclein (αS) protein to amyloid fibrils is a neuropathological hallmark of Parkinson's disease (PD). Growing evidence suggests that extracellular αS aggregation plays a pivotal role in neurodegeneration found in PD in addition to the intracellular αS aggregates in Lewy bodies...

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Detalles Bibliográficos
Autores principales: Das, Sukanya, Pukala, Tara L., Smid, Scott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983024/
https://www.ncbi.nlm.nih.gov/pubmed/29888220
http://dx.doi.org/10.3389/fchem.2018.00181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983024/
https://www.ncbi.nlm.nih.gov/pubmed/29888220
http://dx.doi.org/10.3389/fchem.2018.00181

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