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Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

OBJECTIVE: Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has explored its role in epilepsy development. Thus, this...

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Detalles Bibliográficos
Autores principales: Kanzler, Matthew A., Van Dyke, Adam M., He, Yan, Hewett, James A., Hewett, Sandra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983117/
https://www.ncbi.nlm.nih.gov/pubmed/29881804
http://dx.doi.org/10.1002/epi4.12221