Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia

Moxetumomab pasudotox is a fusion protein of a CD22-targeting antibody and Pseudomonas exotoxin. Minutes of exposure to Moxetumomab achieves similar cell killing than hours of exposure to a novel deimmunized variant against some acute lymphoblastic leukemia (ALL). Because blood levels fall quickly,...

Descripción completa

Detalles Bibliográficos
Autores principales: Müller, Fabian, Cunningham, Tyler, Beers, Richard, Bera, Tapan K., Wayne, Alan S., Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983266/
https://www.ncbi.nlm.nih.gov/pubmed/29883379
http://dx.doi.org/10.3390/toxins10050210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983266/
https://www.ncbi.nlm.nih.gov/pubmed/29883379
http://dx.doi.org/10.3390/toxins10050210

Ejemplares similares