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Domain II of Pseudomonas Exotoxin Is Critical for Efficacy of Bolus Doses in a Xenograft Model of Acute Lymphoblastic Leukemia

Moxetumomab pasudotox is a fusion protein of a CD22-targeting antibody and Pseudomonas exotoxin. Minutes of exposure to Moxetumomab achieves similar cell killing than hours of exposure to a novel deimmunized variant against some acute lymphoblastic leukemia (ALL). Because blood levels fall quickly,...

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Detalles Bibliográficos
Autores principales:	Müller, Fabian, Cunningham, Tyler, Beers, Richard, Bera, Tapan K., Wayne, Alan S., Pastan, Ira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983266/ https://www.ncbi.nlm.nih.gov/pubmed/29883379 http://dx.doi.org/10.3390/toxins10050210

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