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Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons

KEY POINTS: Primary somatosensory neurons normally respond to somatic depolarization with transient spiking but can switch to repetitive spiking under pathological conditions. This switch in spiking pattern reflects a qualitative change in spike initiation dynamics and contributes to the hyperexcita...

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Detalles Bibliográficos
Autores principales: Takkala, Petri, Prescott, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983269/
https://www.ncbi.nlm.nih.gov/pubmed/29601637
http://dx.doi.org/10.1113/JP275580