Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity

One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3′-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-l-tryptophan. Their structures were elucidated on...

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Detalles Bibliográficos
Autores principales: Wang, Cong, Monger, Adeep, Wang, Liping, Fu, Peng, Piyachaturawat, Pawinee, Chairoungdua, Arthit, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983299/
https://www.ncbi.nlm.nih.gov/pubmed/29772796
http://dx.doi.org/10.3390/md16050168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983299/
https://www.ncbi.nlm.nih.gov/pubmed/29772796
http://dx.doi.org/10.3390/md16050168

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