Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation

7-Oxocholesterol (7-OC), 5,6-epoxycholesterol (5,6-EC), and its hydrolysis product cholestane-3β,5α,6β-triol (3β,5α,6β-triol) are normally minor oxysterols in human samples; however, in disease, their levels may be greatly elevated. This is the case in plasma from patients suffering from some lysoso...

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Detalles Bibliográficos
Autores principales: Griffiths, William J., Gilmore, Ian, Yutuc, Eylan, Abdel-Khalik, Jonas, Crick, Peter J., Hearn, Thomas, Dickson, Alison, Bigger, Brian W., Wu, Teresa Hoi-Yee, Goenka, Anu, Ghosh, Arunabha, Jones, Simon A., Wang, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983402/
https://www.ncbi.nlm.nih.gov/pubmed/29626102
http://dx.doi.org/10.1194/jlr.D083246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983402/
https://www.ncbi.nlm.nih.gov/pubmed/29626102
http://dx.doi.org/10.1194/jlr.D083246

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