Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer

Arctigenin is evaluated for antitumor efficacy in patients with pancreatic cancer. It has an inhibitory activity on mitochondrial complex I.Therefore, plasma lactate level of patients after arctigenin administration was evaluated for biomarker of clinical response and/or adverse effect. Plasma lacta...

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Detalles Bibliográficos
Autores principales: Fujioka, Rumi, Mochizuki, Nobuo, Ikeda, Masafumi, Sato, Akihiro, Nomura, Shogo, Owada, Satoshi, Yomoda, Satoshi, Tsuchihara, Katsuya, Kishino, Satoshi, Esumi, Hiroyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983509/
https://www.ncbi.nlm.nih.gov/pubmed/29856804
http://dx.doi.org/10.1371/journal.pone.0198219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983509/
https://www.ncbi.nlm.nih.gov/pubmed/29856804
http://dx.doi.org/10.1371/journal.pone.0198219

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