Novel Ex Vivo Human Osteochondral Explant Model of Knee and Spine Osteoarthritis Enables Assessment of Inflammatory and Drug Treatment Responses

Osteoarthritis of the knee and spine is highly prevalent in modern society, yet a disease-modifying pharmacological treatment remains an unmet clinical need. A major challenge for drug development includes selection of appropriate preclinical models that accurately reflect clinical phenotypes of hum...

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Detalles Bibliográficos
Autores principales: Geurts, Jeroen, Jurić, Doria, Müller, Miriam, Schären, Stefan, Netzer, Cordula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983625/
https://www.ncbi.nlm.nih.gov/pubmed/29710775
http://dx.doi.org/10.3390/ijms19051314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983625/
https://www.ncbi.nlm.nih.gov/pubmed/29710775
http://dx.doi.org/10.3390/ijms19051314

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