Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation

The relaxation activity of E. coli topoisomerase I is required for regulation of global and local DNA supercoiling. The in vivo topoisomerase I enzyme activity is sensitive to lysine acetylation–deacetylation and can affect DNA supercoiling and growth as a result. Nonenzymatic lysine acetylation by...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Qingxuan, Gomez Hernandez, Mario E., Fernandez-Lima, Francisco, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983628/
https://www.ncbi.nlm.nih.gov/pubmed/29751635
http://dx.doi.org/10.3390/ijms19051439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983628/
https://www.ncbi.nlm.nih.gov/pubmed/29751635
http://dx.doi.org/10.3390/ijms19051439

Ejemplares similares