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Biochemical Basis of E. coli Topoisomerase I Relaxation Activity Reduction by Nonenzymatic Lysine Acetylation

The relaxation activity of E. coli topoisomerase I is required for regulation of global and local DNA supercoiling. The in vivo topoisomerase I enzyme activity is sensitive to lysine acetylation–deacetylation and can affect DNA supercoiling and growth as a result. Nonenzymatic lysine acetylation by...

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Detalles Bibliográficos
Autores principales:	Zhou, Qingxuan, Gomez Hernandez, Mario E., Fernandez-Lima, Francisco, Tse-Dinh, Yuk-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983628/ https://www.ncbi.nlm.nih.gov/pubmed/29751635 http://dx.doi.org/10.3390/ijms19051439

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