Computational Characterization of Small Molecules Binding to the Human XPF Active Site and Virtual Screening to Identify Potential New DNA Repair Inhibitors Targeting the ERCC1-XPF Endonuclease

The DNA excision repair protein ERCC-1-DNA repair endonuclease XPF (ERCC1-XPF) is a heterodimeric endonuclease essential for the nucleotide excision repair (NER) DNA repair pathway. Although its activity is required to maintain genome integrity in healthy cells, ERCC1-XPF can counteract the effect o...

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Detalles Bibliográficos
Autores principales: Gentile, Francesco, Barakat, Khaled H., Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983712/
https://www.ncbi.nlm.nih.gov/pubmed/29710850
http://dx.doi.org/10.3390/ijms19051328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983712/
https://www.ncbi.nlm.nih.gov/pubmed/29710850
http://dx.doi.org/10.3390/ijms19051328

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